Abstract： Objective： To observe the clinical effect of point application combined with abdominal massage on schizophrenia. Methods：A total of 120 cases of patients with schizophrenia were randomly divided into the observation group and the control group，60 cases in each group. The control group was given routine treatment of antipsychotic medicine，and the observation group was additionally given point application combined with abdominal massage based on the treatment of the control group. Both groups were continuously treated for eight weeks. After treatment，clinical effect，quality of life，as well as scores of Positive and Negative Symptom Scale(PANSS)，Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale(SDS) were analyzed and compare in the two groups. Results：The total effective rate was 76.67% in the observation group，higher than that of 58.33% in the control group，the difference being significant(P＜0.05). Before treatment，when compared scores of Positive Symptom Scale，Negative Symptom Scale，and General Psychopathology Scale between the two groups，there was no significance in the difference(P＞0.05)；after treatment，the scores above in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of SAS and SDS scores between the two groups(P＞0.05). After treatment， SAS and SDS scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，when compared scores of mental health，physical health，material living，and social function between the two groups，there was no significance in the difference(P＞0.05)；after treatment， the scores of the four dimensions above in the two groups were increased when compared with those before treatment(P＜ 0.05)， and the scores of quality of life in the observation group were higher than those in the control group(P＜0.05). Conclusion：Based on routine treatment，the therapy of point application combined with abdominal massage in treatment of schizophrenia can enhance the curative effect and life quality，relieve clinical symptoms，and improve anxiety and depression.