Abstract：Objective：To observe the clinical effect of Xingnaojing injection combined with Xuebijing injection on patients with acute organophosphorus pesticide poisoning(AOPP) complicated with coma. Methods： Seventy- four patients with severe AOPP complicated with coma were selected and divided into the treatment group and the conventional group according to random number table method， 37 cases in each group. The conventional group was given gastric lavage， nutrition，fluid replenishment，correction of acid-base and electrolyte disorders，iodophodine，Changtuoning(penehyclidine hydrochloride injection) and other conventional treatments，while the treatment group was given Xingnaojing combined with Xuebijing injection based on the treatment of the conventional group. Both groups were treated for five days. The clinical indexes(dosage of Changtuoning， recovery time of 60% cholinesterase activity， conscious time， length of hospital stay， success rate of rescue) were compared between the two groups. Changes in serum inflammatory factors(TNF-α，IL-6，IL-8、 IL-10) and myocardial injury Creatine kinase(CK)、Lactate dehydrogenase(LDH)、Aspartate aminotransferase(AST)、creatine kinase isoenzymes(CK- MB) before and after treatment were observed between the two groups， and the incidence of complications between the two groups were observed. Results：During the treatment，the dosage of Changtuoning in the treatment group was less than that in the conventional group； the recovery time of 60% cholinesterase activity， the conscious time and the hospitalization time were shorter than those in the conventional group；and the success rate of rescue was higher than that in the conventional group，differences being significant(P＜0.05). After treatment，the levels of TNF-α， IL- 6， IL- 8 and CRP in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of the above four indexes in the treatment group were lower than those in the conventional group(P＜0.05). After treatment，the levels of CK，LDH，AST and CK-MB in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of the above four indexes in the treatment group were lower than those in the conventional group(P＜0.05). The total incidence of complications was 21.62% in the treatment group，lower than those of 51.35% in the conventional group， the difference being significant(P＜0.05). Conclusions： The therapy of Xingnaojing injection combined with Xuebijing injection has significant curative effect on AOPP patients complicated with coma， which can effectively reduce medicine dosage， shorten hospitalization time and conscious time， improve the success rate of rescue，and reduce complications，with high safety.