Abstract：Objective：To observe the clinical effect of Xuefu Zhuyu tang combined with western medicine for unstable angina pectoris of coronary heart disease and its effect on antioxidant capacity and matrix metalloproteinase- 6(MMP-6) and matrix metalloproteinase- 9(MMP- 9) in serum. Methods： A total of 74 cases of patients with unstable angina pectoris of coronary heart disease were selected as the research objects， and divided into the study group and the control group according to the random number table method， 37 cases in each group. Both groups were given basic symptomatic treatment， and the study group was additionally given Xuefu Zhuyu tang. Both groups were treated for eight weeks. The clinical effects in the two groups were observed. Before and after treatment，Chinese medicine syndrome scores and heart function indexes including left ventricle ejection fraction(LVEF)， left ventricular end diastolic volume(LVEDV) and left ventricular end systolic volume(LVESV) in the two groups were compared. Before and after treatment，the activity of plasma superoxide dismutase(SOD)， the contents of matrix metalloproteinase- 6(MMP- 6) in serum and the levels of matrix metalloproteinase- 9(MMP- 9) in the two groups were compared. Results： After treatment， the total effective rate was 97.30% in the study group，higher than that of 83.78% in the control group，the difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the score in the study group was lower than that in the control group，differences being significant(P＜0.05). After treatment，LVEF values in the two groups were increased when compared with those before treatment，and the values of LVEDV and LVESV were decreased， differences being significant(P＜0.05)； LVEF value in the study group was significantly higher than that in the control group， and the values of LVEDV and LVESV were lower， differences being significant(P＜0.05). After treatment， SOD levels in the two groups were increased when compared with those before treatment，and the levels of MMP-6 and MMP-9 were decreased，differences being significant(P＜0.05)；SOD level in the study group was higher than that in the control group，and the levels of MMP-6 and MMP-9 were lower，differences being significant(P＜0.05). Conclusion： The therapy of Xuefu Zhuyu tang combined with western medicine for unstable angina pectoris of coronary heart disease can effectively improve the blood antioxidant capacity， with a good clinical effect on relieving clinical symptoms and improving heart function.