目的：观察丹紫康膝冲剂联合温针灸治疗肝肾亏虚型膝骨关节炎的临床疗效。方法：将120 例肝 肾亏虚型膝骨关节炎患者按随机数字表法分为4 组（A、B、C、D），每组30 例。所有患者均予常规股四头肌 功能锻炼和健康宣教，在此基础上，A 组口服塞来昔布胶囊治疗，B 组采用温针灸治疗，C 组口服丹紫康膝冲 剂治疗，D 组采用丹紫康膝冲剂联合温针灸治疗，治疗4 周。评价4 组临床疗效，检测4 组治疗前后白细胞介 素-8（IL-8）、血管内皮生长因子（VEGF）、成纤维细胞生长因子（FGF-2） 水平，比较4 组治疗前后西安大 略和麦克马斯特大学骨关节炎指数评分（WOMAC）、视觉模拟评分法（VAS） 评分、生活质量评分及中医证候 积分，统计4 组不良反应发生率。结果：D 组总有效率为93.33%，高于其它3 组（P＜0.05）。治疗后，4 组 VAS 评分、WOMAC 评分、中医证候积分、血清IL-8、VEGF 水平较治疗前降低（P＜0.05）；且D 组VAS 评 分、WOMAC 评分、中医证候积分、血清IL-8、VEGF 水平低于其他3 组（P＜0.05）。治疗后，4 组FGF-2 水 平、生活质量评分较治疗前升高（P＜0.05）；且D 组FGF-2 水平、生活质量评分高于其他3 组（P＜0.05）。 结论：丹紫康膝冲剂联合温针灸治疗肝肾亏虚型膝骨关节炎可明显缓解膝关节肿痛，减轻炎症反应，改善膝关 节功能，其机制可能是通过降低血清IL-8、VGEF 水平，促进FGF-2 生成以消炎镇痛、保护关节软骨。
Abstract：Objective：To observe the clinical effect of Danzi Kangxi Granules combined with warmingneedle moxibustion for knee osteoarthritis of liver-kidney depletion type. Methods：A total of 120 cases of patients with knee osteoarthritis of liver-kidney depletion type were divided into four groups (A，B，C，D) according to the random number table method，with 30 cases in each group. All patients were treated with routine quadriceps functional exercise and health education； the Group A was additionally given the oral administration of Celeoxib Capsules， the Group B was additionally treated with warming- needle moxibustion，the Group C was additionally given the oral administration of Danzi Kangxi Granules，and the Group D was additionally treated with Danzi Kangxi Granules combined with warming-needle moxibustion. All the groups were treated for 4 weeks. The clinical effects in the four groups were evaluated；the levels of interleukin- 8 (IL- 8)，vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF- 2) were detected before and after treatment in the four groups； the Western Ontario and McMaster University Osteoarthritis Index (WOMAC)， Visual Analogue Scale (VAS) scores， quality of life scores and traditional Chinese medicine (TCM) syndrome scores were compared before and after treatment among the four groups； the incidence of adverse reactions in the four groups was analyzed. Results： The total effective rate was 93.33% in the Group D，higher than those in the other three groups (P＜0.05). After treatment， VAS scores，WOMAC scores，TCM syndrome scores，and the levels of IL- 8 and VEGF in serum in the four groups were decreased when compared with those before treatment (P＜0.05). The VAS score， WOMAC score，TCM syndrome score，and the levels of IL- 8 and VEGF in serum in the Group D were lower than those in the other three groups (P＜0.05). After treatment， FGF- 2 levels and quality of life scores in the four groups were increased when compared with those before treatment (P＜0.05)，and the FGF- 2 levels and quality of life scores were higher than those in the other three groups (P＜0.05). Conclusion：Danzi Kangxi Granules combined with warming-needle moxibustion for knee osteoarthritis of liver- kidney depletion type can significantly relieve swelling and pain in knee joints，reduce inflammatory responses and improve knee joint function. The mechanism may be related to reducing the levels of IL- 8 and VGEF in serum， promoting the production of FGF- 2 to reduce inflammation， relieve analgesia and protect articular cartilage.