Abstract： Objective： To observe the clinical effect of sticking with natrii sulfas exsiccatus combined with borneolum syntheticum preventing and treating children with pain after azithromycin infusion. Methods：A total of 102 cases of children with respiratory tract infection who received intravenous drip with azithromycin were divided into the control group and the experiment group according to the random number table method， 51 cases in each group. The control group was given infusion by routine puncture method，and the experiment group was additionally stuck with natrii sulfas exsiccatus combined with borneolum syntheticum based on the treatment of the control group. The pain degree of transfusion puncture， exosmosis rate of medical solution， incidence of phlebitis and nursing satisfaction in the two groups were compared. Results：The pain score of transfusion puncture in the experiment group was(3.34±3.17) points，lower than that of(5.03± 2.46) points in the control group(P＜0.05). The rates of moderate and severe pain of transfusion puncture were 13.73% and 3.92% respectively in the experiment group，lower than those of 31.37% and 19.61% in the control group(P＜0.05). The exosmosis rate of medical solution and the incidence of phlebitis were 1.96% and 37.25% respectively in the experiment group，lower than those of 13.73% and 68.63% in the control group(P＜0.05). The total nursing satisfaction was 98.04% in the experiment group，significantly higher than that of 84.31% in the control group(P＜0.05). Conclusion：The application of sticking with natrii sulfas exsiccatus combined with borneolum syntheticum can relieve the pain of children after azithromycin infusion，reduce the incidence of adverse events on infusion and improve the nursing satisfaction.