Objective： To observe the effect of deguelin inducing programmed necrosis of human gastric carcinoma SGC7901/VCR cells.Methods：Detected the changes of apoptosis and necrosis of human gastric carcinoma SGC7901/VCR cells before and after the induction of deguelin via Hoechst 33342/propidium iodide(PI)staining fluorescence microscope and Annexin V-FITC/PI flow cytometer；observed the changes of the ultrastructure of human gastric carcinoma SGC7901/VCR cells before and after the induction of deguelin via transmission electron microscope；detected the expression of RIP1 and RIP3 protein via Western blot.Results：Comparing with the control group，there were numerous dead cells being found in the deguelin group，and there was no significant difference being found in the apoptosis rate，while the necrosis rate was significantly increased(P＜ 0.05).Detected by transmission electron microscope，nuclear swelling and evagination，chromatin condensation and numerous necrosomes forming around the nuclear membrane were observed in the deguelin group.As the results of West blot showed，the expression of RIP1 and RIP3 protein of cells in the deguelin group was significantly elevated，and was gradually increased as time extended.Conclusion：After acting on human gastric carcinoma SGC7901/VCR cells，deguelin can induce their programmed necrosis，and its mechanism needs to be further studied.