Objectives：To study the effect of Yishenkang pills on the content of fasting blood glucose and fasting insulin in rats with insulin resistance.Methods：Among 60 SD male rats，10 rats were given the basic feed randomly as the blank group，50 rats were fed with high fat and high carbohydrate diet combined with intraperitoneal injection of streptozotocin(STZ)to establish insulin resistance model.After eight weeks，divided successful modeling rats randomly into model group，Yishenkang pill high dose group，Yishenkang pill medium dose group，Yishenkang pill low dose group，and metform group.Yishenkang pill high，medium，low dose groups were respectively given 150 mg/(kg·d)，300 mg/(kg·d)and 600 mg/(kg·d)of Yishenkang suspension by gavage.Metform group was given 250 mg/(kg·d)of metform suspension by gavage.The model group was given equivalent dose of normal saline by gavage.All groups continued medication for 4 weeks.Determined levels of fasting blood glucose(FBG)and fasting insulin(FINS)in these groups before and after medication.Results：In comparison with the blank group， body mass as well as levels of FBG and FINS in the model group were remarkably increased，differences being significant(P ＜ 0.05)，which indicated that the model was valid.After four weeks of medication，in comparison to those before treatment，levels of FBG and FINS in Yishenkang pill medium and high dose groups as well as metform group were remarkably decreased，while FINS levels in Yishenkang pill low dose group were remarkably decreased(P＜ 0.05).After medication，in comparison to the model group，levels of FBG and FINS in Yishenkang pill high，medium，low dose group and metform group were remarkably decreased(P＜0.05).In comparison to metform group，levels of FBG and FINS in Yishenkang pill low dose group were higher(P＜ 0.05)，while levels of FBG and FINS in Yishenkang pill high dose group and medium dose group showed no significant difference(P＞0.05).Conclusion：Yishenkang pills can significantly decrease the level of insulin resistance to FBG and FINS，having a certain curative effect on insulin resistance of type 2 diabetes.