Objective：To study the atrophy reversal effect of Tiepi Fengdou granules in treating model rats with chronicatrophic gastritis(CAG)induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG).Methods：Wistar rats were fed with 167 μg/mL of MNNG water solution to establish model rats of CAG.After modeling，divided the model rats into the model group，Tiepi Fengdou granule group and folic acid tablets group，while untreated rats were in normal group.By gavage，the model group was given saline solution，Tiepi Fengdou granule group was given 1.2 g/(kg·d)of Tiepi Fengdou granules and folic acid tablets group was given 5.0 mg/(kg·d)of folic acid tablets.Observed body mass and situation of gastric tissue histopathology of the rats.Results：Compared with those in the normal group，in the model group，weight of rats was decreased remarkably，inflammation grade was higher，the number of inherent glands and gland thickness were remarkably reduced，the chief cells were remarkably decreased，and the number of atypical hyperplasia and intestinal metaplasia in gastric tissue was increased before treatment and after 8-week-medication，differences being significant(P＜0.05，P＜0.01).Compared with the model group，in Tiepi Fengdou granule group and folic acid tablets group，the levels of body mass were significantly increased，levels of inflammation were decreased，the number of inherent glands and gland thickness evdently was increased，the situdation of atypical hyperplasia and intestinal metaplasia in gastric tissue was better and their number was evidently decreased after 8-week-medication，differences being significant(P＜0.05，P＜0.01).Compared with that in folic acid tablets group，body mass in Tiepi Fengdou granule group was higher，the difference being significant(P＜0.05).Conclusion：Tiepi Fengdou granules and folic acid tablets have a greatly curative effect on CAG rats models，which can reduce the loss of body mass and the level of gastric mucosa inflammation，gland atrophy as well as atypical hyperplasia.