Objective：To observe the clinical effect of Shexiang Baoxin pills combined with routine western medicine for angina pectoris after percutaneous coronary intervention(PCI)of patients with coronary heart disease.Methods：Divided 82 cases of patients with angina pectoris of coronary heart disease after PCI into the treatment group and the control group randomly，41 cases in each group.Both groups were given secondary prevention of western medicine treatment for coronary heart disease，while the treatment group was additionally receivedShexiang Baoxin pills.Evaluated the curative effect of angina pectoris and electrocardiogram after treatment，and recorded seizure times and duration of angina pectoris as well as application of nitroglycerin.Results：The total effective rate of curative effect of angina pectoris was 90.24%in the treatment group and was70.73% in the control group， the difference being significant(P＜0.05).The total effectiverate of electrocardiogram was 78.05%in the treatment group and was 48.78%in the control group，the difference being significant(P＜0.05).After treatment，the seizure times and duration of angina pectoris in both groups were less or shorter than those before treatment(P＜0.05).The seizure times and duration of angina pectoris in the treatment group were less or shorter than those in the control group(P＜0.05).After treatment，application of nitroglycerin of both groups was reduced when compared with that before treatment(P＜0.05)；the application of nitroglycerin in the treatment group was lower than that in the control group(P＜0.05).Conclusion：Shexiang Baoxin pills combined with routine western medicine has significant effect in treating angina pectoris after PCI of patients with coronary heart disease，which can effectively relieve the angina pectoris symptoms and reduce the application amount of nitroglycerin.