Objective： To observe the clinical effect of Wumei pills for cough induced by cold with upward hot and downward cold syndrome and the result of infrared thermal imaging technology.Methods：Collected 60 cases of patients with cough induced by cold with upward hot and downward cold syndrome，and randomly divided them into the treatment group and the control group.The treatment group was given modified Wumei pills，and the control group was treated with compound glycyrrhiza oral solution.Observed the clinical effect after one week of treatment，evaluated scores of cough and expectoration，and detected the body surface temperature in chest and abdomen with the infrared thermal imaging technology.Results：After one week of treatment，the total effective rate was 86.7%in the treatment group and 76.7%in the control group，the difference being not significant(P＞0.05).Scores of cough and expectoration were declined in both groups in comparison with those before treatment(P ＜ 0.01)；scores of the two indexes in the treatment group were both lower than those in the control group(P＜0.01).The pectroal and abdominal body temperature in the treatment group were both higher than those before treatment and those in the control group(P＜0.01).Conclusion：With certain clinical effect in treating cough induced by cold with upward hot and downward cold syndrome，Wumei pills can improve symptoms of patients significantly.Infrared thermal imaging technology provides an image method of quantitative evaluation and a basis of objective effect evaluation.