Objective：To observe the curative effect of Yangwei Yuwei tang for chronic atrophic gastritis(CAG)and the effect on inflammatory factor C-reactive protein(CRP)，interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α).Methods：Selected 86 cases of patients diagnosed with CAG of spleen and stomach deficiency type，and divided them into two groups randomly， 43 cases in each group.The control group was given vitacoenzyme tablets， clarithromycin disperse tablets，amoxicillin capsules，and omeprazole enteric-coated capsules，while the treatment group was given Yangwei Yuwei tang.Both groups receivedtreatment for three months.Observed the curative effect and levels of CRP，IL-6 and TNF-αin the two groups before and after treatment.Results：After treatment，the total effective rate was 95.35%in the treatment group and 79.07%in the control group，the difference being significant(P＜0.05).Levels of serum CRP，IL-6 and TNF-α of both groups were decreased when compared with those before treatment(P＜0.05)，and levels of the three indexes in the treatment group were lower than those in the control group(P＜0.05).Conclusion：Yangwei Yuwei tang has good clinical effect for CAG patients with spleen and stomach deficiency syndrome，and it can reduce chronic inflammatory response.