Objective： To observe the clinical effect of Jianwei Xiaozhang tablets for nonalcoholic fatty liver disease(NAFLD).Methods：Divided 60 cases of patients with NAFLD into the treatment group and the control group randomly，30 cases in each group.The treatment group was given Jianwei Xiaozhang tablets，while the control group was given essentiale capsules.Both groups receivedtreatment for 12 weeks.Observed the changes of main clinical symptom scores，liver function indexes which includes alanine transaminase(ALT)，aspartate aminotransferase(AST)，and serum lipids indexes which includes triglyceride(TG)，total cholesterol(TC)，as well as liver ultrasound.Results：After treatment，the total effective rate was 90.00%in the treatment group and was 83.33%in the control group，there being no significant difference(P＞0.05).Levels of ALT and AST of both groups were declined when compared with those before treatment(P＜0.05)，while levels of the two indexes in the treatment group were lower than those in the control group(P＜0.05).Levels of TC，TG and scores of main clinical symptom，liver ultrasound were declined when compared with those before treatment(P＜0.05).No significance was found in the comparison of levels of TC，TG and scores of liver ultrasound of both groups(P＞0.05)，while scores of main clinical symptom of the treatment group were lower than those of the control group(P＜0.05).Conclusion：In terms of curativeeffect and improvement of blood lipid metabolism，Jianwei Xiaozhang tablets are well-matched in treating NAFLD when compared with essentiale capsules，while it has clear advantages in improving clinical symptoms and liver function.