Objective：To observe the clinical effect of modified Quyu Xiezhuo tang combined with western medicine for chronic renal failure.Methods：Selected 84 cases of patients with chronic renal failure with the syndrome of qi deficiency and blood stasis as well as endogenous pathogenic dampness，and divided them into the observation group and the control group randomly.Based on the treatment of primary diseases，the control group was given compound α-ketoacid tablets，while the observation group additionally receivedmodified Quyu Xiezhuo tang apart from the same treatment in the control group.Both groups continuously received the treatment for 3 months.Observed changes of main symptoms and adverse reaction in both groups.Determined the renal function indexes[serum creatinine(SCr)，blood urine nitrogen(BUN)， uric acid(UA)， and endogenous creatinine clearance(CCr)]as well as hemoreology indexes in both groups.Results：After treatment，the total effective rate was 83.3%in the control group and 54.8%in the observation group，the difference being significant(P＜0.05).Levels of SCr，UA and BUN in both groups were reduced when compared with those before treatment，while levels of CCr were increased when compared with those before treatment，differences being significant(P ＜ 0.05).Levels of SCr，UA，BUN，and CCr in the observation group were all superior to those in the control group，differences being significant(P＜0.05).Plasma fibrinogen，plasma viscosity and erythrocyte aggregation indexes in both groups were all declined，comparing with those before treatment，differences all being significant(P ＜ 0.05).The three indexes in the observation group were all lower than those in the control group，differences being significant(P ＜ 0.05).Conclusion：The therapy of modified Quyu Xiezhuo tang based on routine treatment can markedly improve the renal function and clinical effect，which has high safety and great significance in clinical practice.