Objective： To observe the curative effect of integrated Chinese and western medicine therapy for acutepyelonephritis with bladder damp-heat syndrome and its effect on immunologic function of patients.Methods：Divided 104 cases of patients with acute pyelonephritis with bladder damp-heat syndrome into the observation group and the control group randomly，52 cases in each group.Both groups receivedcefalexin tablets，norfloxacin capsules and sodium bicarbonate tablets for treatment，while the observation group additionally received Xiere Sanyu Tonglin tang.Both groups received treatment for two weeks.Chinese medicine syndrome scores and the clinical effect of the two groups were compared.Levels of serum IgA，IgG and IgM of the two groups before and after treatment were detected.Results：After treatment，scores of frequent micturition，urodynia， urgency of urination， and pain in waist and knee of both groups were decreased when compared with those before treatment(P＜0.01)；the above syndrome scores of the observation group were all lower than those of the control group，differences being significant(P＜0.01).The total effective rate was 98.08%in the observation group and was 84.62%in the control group，the difference being significant(P＜0.05).Levels of serum IgA，IgG and IgM in both groups were increased than those before treatment(P＜0.01)，and levels of serum IgA，IgG and IgM in the observation group were all higher than those in the control group，differences being significant(P＜0.01).Conclusion：Integrated Chinese and western medicine therapy for acute pyelonephritis with bladder damp-heat syndrome has significant curative effect，which can effectively improve clinical symptoms and immunologic function of patients.