Objective：To observe clinical effect of dispelling wind and dampness itching medicated bath therapy for uremic pruritus(UP).Methods：Divided 30 UP patients into the treatment group and control group randomly，15 cases in each group.Both groups receivedroutine hemodialysis and other basic treatments.The control group additionally received clean water bath，while the treatmentgroup additionally received dispelling wind and dampness itching medicated bath.Both groups filled in life quality questionnaires(SF-36)and Dirk R Kuypers pruritus score questionnaires before treatment and after two weeks treatment.Compared the changes of life qualities and laboratory indexes of both groups before and after treatment.Results：After treatment，all dimension scores of patients in the treatment group were increased when compared with those before treatment，differences being significant(P＜0.05)；compared with the control group，the differences being significant(P＜0.05).After treatment，pruritus symptoms score in the treatment group was decreased when compared with that before treatment，and the score in the treatment group was lower than thatin the controlgroup， the differences being significant(P＜0.05).Levels ofserum phosphorus， iPTH， β2microglobulin and C-reactiveprotein in both groupsweredecreased when compared with those beforetreatment，differences being significant(P＜0.05)；and the decrease of above indexes in the treatment group were more evident than those in the control group，differences being significant(P＜0.05).No significance was found in the comparison of levels of blood calcium，serum potassium and Alb between the two groups(P＞0.05).Conclusion：Dispelling wind and dampness itching medicated bath therapy can effectively improve quality of life and clinical symptoms of UP patients，which deserves clinical application.