Objective： To observe the clinical effect of sodium hyaluronate combined with Xibitong tang for knee osteoarthritis in senile patients.Methods： According to random number table， divided 80 cases of patients with knee osteoarthritis into two groups randomly，40 cases in each group.Both groups receivedsodium hyaluronate by intra-articular injection for treatment，while the observation group additionally received Xibitong tang.The curative effect was evaluated after 5 weeks of treatment.Observed all indexes before and after treatment such as Lequesne index，visual analogue score(VAS)，levels of tumor necrosis factor- α (TNF- α)， interleukin-1(IL-1)， matrix metalloproteinase-3(MMP-3)， and C-reactive protein(CRP)in peripheral venous blood，as well as score of joint swelling and tenderness.The clinical effect was evaluated as well.Results：After treatment，Lequesne indexes，VAS，and scores of joint swelling and tenderness in both groups were lower than those before treatment，differences being significant(P ＜ 0.05).The decreased degrees of Lequesne indexes，VAS，and scores of joint swelling and tenderness in the observation group were superior to those in the control group，differences being significant(P ＜ 0.05).After treatment，levels of TNF-α，IL-1，MMP-3，and CRP in peripheral venous blood in the observation group were significantly decreased，differences being significant(P ＜ 0.05)；the decreased degrees of levels of TNF-α，IL-1，MMP-3，and CRP in peripheral venous blood in the observation group were superior to those in the control group，differences being significant(P＜ 0.05).The total effective rate was 95.0%in the observation group and 80.0%in the controlgroup，the difference being significant(P＜0.05).Conclusion：The therapy of sodium hyaluronate combined with Xibitong tang for knee osteoarthritis in senile patients can improve knee function and symptoms such as swelling，tenderness，pain，and rigidity，and decrease levels of TNF-α，IL-1，MMP-3，and CRP.