Objective：To observe the curative effect of Xianzhi Fengsui tang for rheumatoid arthritis and the expression levels of osteoprotegerin(OPG)in peripheral blood.Methods：Divided 60 cases of patients with rheumatoid arthritis according with the criteria of study into the treatment group and the control group randomly，30 cases in each group.Both groups receivednon-steroidal anti-inflammatory drugs，methotrexate and Caltrate-D tablets，while the treatment group additionally received Xianzhi Fengsui tang orally.Results：After treatment，morning stiffness，grip strength，the number of painful joints，scores of articular rest pain，erythrocyte sedimentation rata(ESR)，C-reactive protein(CRP)，rheumatoid factor(RF)，bone mineral density(BMD)，and osteoprotegerin(OPG)were respectively compared between the two groups before and after treatment，differences being significant(P ＜ 0.05).After treatment，morning stiffness，grip strength，the number of painful joints，ESR，RF，BMD，OPG in both groups were compared，differences being significant(P ＜ 0.05).The results suggested that the treatment group was better than the control group in improving morning stiffness，grip strength and limbs activity with painful joints，and it was superior to the control group in expression levels of OPG and BMD.There were two cases of adverse reaction being found in both groups，mainly including nausea and vomiting，rash，dyspepsia，and diarrhea.Cases of adverse reaction in both groups were all mild and tolerable for completing the clinical observation.Conclusion：Xianzhi Fengsui tang can improve clinical symptoms of patients with rheumatoid arthritis，enhance expression levels of osteoprotegerin and increase bone mineral density.