Objective： To observe the clinical effect of Guizhi Fuzi tang combined with routine western therapy for rheumatoid arthritis.Methods：Divided 96 patients with rheumatoid arthritis into the combination group and the control group randomly，48 cases in each group.Both groups receivedroutine western therapy for treatment，while the combination group additionally received Guizhi Fuzi tang.Changes of main symptoms including swollen joint count，pain joint count and time of morning stiffness of patients in both groups were compared.Pain degrees of patients were evaluated by visual analogue scale(VAS).Changes of illness of patients were evaluated by rheumatoid arthritis disease activity score(DAS28).Levels of hypersensitive C-reactive protein(hs-CRP)， rheumatoid factor(RF)， erythrocyte sedimentation rate(ESR)， interleukin 17(IL-17)，and tumor necrosis factor related ligand 1A(TL1A)before and after treatment were detected in both groups.Results：Compared the clinical effect between the two groups，the difference being significant(P ＜ 0.05)，and the curative effect of the combination group was better than that of the control group.Swollen joint count， pain joint count， time of morning stiffness， VAS scores and DAS28 scores after treatment in both groups were significantly lower than before treatment，differences being significant(P ＜ 0.05).After treatment，swollen joint count，pain joint count，time of morning stiffness，VAS scores and DAS28 scores in the combination group were lower than those in the control group，differences being significant(P＜ 0.05).Levels of hs-CRP，RF，ESR，IL-17 and TL1A after treatment in both groups were significantly lower than those before treatment，differences being significant(P ＜ 0.05).After treatment，levels of hs-CRP，RF，ESR，IL-17 and TL1A in the combination group were significantly lower than those in the control group，differences being significant(P＜0.05).Conclusion：The therapy of Guizhi Fuzi tang combined with routine western therapy can improve clinical symptoms of patients with rheumatoid arthritis and relieve inflammation.