Objective： To observe the clinical effect of fumigation and washing with Huoxue Zhitong powder combined with open reduction and internal fixation for Lisfranc joint injury.Methods：Divided 126 cases of patients with Lisfranc joint injury into two groups randomly，63 cases in each group.Both groups receivedthe routine therapy of open reduction and internal fixation，while the observation group additionally received fumigation and washing with Houxie Zhitong powder.Observed the clinical effect in both groups，and analyzed degrees of pain and foot swelling of two groups on the 10th，20th，30th and 40th day after treatment.Results：The total effective rate was 93.65%in the observation group and was 77.78%in the control group，the difference being significant(P＜0.05)；after treatment，pain scores of visual analog scale(VAS)and foot swelling degrees of the two groups both showed downtrend evidently with the time，and pain scores of VAS and foot swelling degrees of the observation group were both lower than those of the control group on the 10th，20th，30th and 40th day after treatment，differences being significant(P＜0.05).Conclusion：Fumigation and washing with Huoxue Zhitong powder combined with open reduction and internal fixation can effectively relieve pain and edema of periarticular tissue.