Objective： To observe the clinical effect of Yishen Jiangu prescription combined with 99Tc-MDP for osteoporosis of kidney asthenia and blood stasis type.Methods：Divided 86 cases of patients randomly into two groups，43 cases in each group.The treatment group receivedintravenous drip of 99Tc-MDP combined with oral administration of granules of Yishen Jiangu prescription，while the control group simply received intravenous drip of 99Tc-MDP.Both groups received treatment for 10-15 days(10 days for men，15 days for women)as one course，3 courses for each year.Observed and compared changes of bone mineral density(BMD)，the clinical effect and adverse reaction between the both groups before and after treatment.Results： After treatment， compared L1～L4BMD and femoral neck BMD of both groups respectively to those before treatment，differences were significant(P＜0.05).After treatment，compared L1～L4BMD and femoral neck BMD of both groups，differences were significant(P＜0.05).Compared the clinical effect of both groups，there was no significance in difference(P＞0.05).After half a year of follow-up，there was one case of recurrence in the treatment group and two cases of recurrence in the control group，while the curative effect was consolidated in other cases.There was no incidence of adverse reaction in both groups during the observation.Conclusion：The therapy of Yishen Jiangu prescription combined with 99Tc-MDP can effectively improve BMD of patients with osteoporosis，and it is superior to simple 99Tc-MDP treatment.