Objective： To observe the clinical effect of jianpi bushen tang for secondary renovascular osteoporosis.Methods：Divided 300 cases of patients enrolled in the observation into two groups randomly，150 cases in each group.Both groups receivedsalmon calcitonin and alendronate sodium based on the treatment for primary disease，while the observation group additionally received jianpi bushen tang.Both groups were treated for 12 weeks.After treatment，respectively compared pain relief，changes of bone mineral density(BMD)， bone marker， the occurrence rate of new fractures， and 25-hydroxyvitamin D in the two groups with those before treatment.Results： After treatment， VAS of pain， 25-hydroxyvitamin D and osteocalcin(OC)as an bone turnover marker in both groups were compared with those before treatment，differences being significant(P ＜ 0.05)，and the intergroup comparison showed significance in differences(P ＜0.05).After treatment， BMD of L1～L4lumbar vertebra and femoral neck were compared with those before treatment，differences being significant(P ＜ 0.05)，and the intergroup comparison of BMD of L1～L4lumbar vertebra and femoral neck displayed significance in differences(P＜0.05).The total effective rate was 73.33%in the control group and 93.33%in the observation group，the difference being significant(P＜0.05).The occurrence rate of new fractures in both groups was compared，the difference being significant(P ＜ 0.05).Conclusion：Additional application of jianpi bushen tang based on the treatment for secondary renovascular osteoporosis can significantly release pain in patients，increase bone mineral density and enhance the clinical effect.