Objective： To observe the clinical effect of sequential cycle adjustment therapy of liver-kidney-spleen for dysfunction of ovarian reserve(DOR).Methods：Selected 78 cases of DOR patients as study subjects，and randomly divided them into the treatment group and the control group，respectively 40 cases and 38 cases in each group.The treatment group was given sequential cycle adjustment therapy of liver-kidney-spleen，while the control group receivedClimen for treatment.Observed the changes of symptom score as well as levels of serum sex hormone indexes[follicle-stimulating hormone(FSH)，luteinizing hormone(LH)and anti-mullerian hormone(AMH)]in both groups before and after treatment，and evaluated the curative effect.Results：After treatment，hypomenorrhea scores and total symptom scores in both groups were lower than those before treatment(P＜0.05)，and the two scores in the treatment group were both declined more evidently than those in the control group(P＜0.05).After treatment，levels of FSH and LH in the two groups were both lower than those before treatment(P＜0.05)，while AMH levels in both groups were higher than those before treatment(P＜0.05).The comparisons of the levels of three sex hormone indexes between the two groups showed no significance in differences(P＞0.05).The total effective rate was 90.0%in the treatment group and 71.0%in the control group，the difference being significant(P＜0.05).Conclusion：The sequential cycle adjustment therapy of liver-kidney-spleen for dysfunction of ovarian reserve can effectively improve menstrual cycle and menstrual quantity of patients as well as regulate sex hormone indexes，being more effective than Climen therapy.