Objective：To observe the distribution law of Chinese medicine(CM)constitution types among 103 cases of premature ovarian failure patients in Wenzhou，and to compare the sex hormone level in different CM constitution type.Methods：Identified the CM constitution types of 103 cases of premature ovarian failure patients，and counted the cases number as well as the proportion of each CM constitution type.Recorded and compared levels of follicle stimulating hormone(FSH)，luteinizing hormone(LH)and estrogen(E2)in premature ovarian failure patients with different CM constitution types.Results： Among 103 cases of premature ovarian failure patients， 95 cases had abnormal constitution， accounting for 92.23%.The proportions of other constitution types were as follow：yin-deficiency constitution(29.13%)＞qi-stagnation constitution(19.42%)＞qi-deficiency constitution(15.53%)＞yang-deficiency constitution(14.56%)＞dampness-heat constitution(6.80%)＞ phlegm-dampness constitution(3.88%)＞blood stasis constitution(2.91%).Levels of E2，FSH and LH in patients with yin-deficiency constitution， qi-stagnation constitution， yang-deficiency constitution， and qi-deficiency constitution were analyzed by one-way ANOVA，differences being significant(P＜0.05).Comparing E2levels in patients with four constitution types，it was found that qi-deficiency constitution＞yang-deficiency constitution＞qi-stagnation constitution＞yin-deficiency constitution(P＜0.05).Comparing LH levels in patients with four constitution types， the results wereyin-deficiency constitution＞qi-stagnation constitution(P＜0.05)and yin-deficiency constitution＞qi-deficiency constitution(P＜0.05).There was no significant difference being found in the comparisons of LH levels between yin-deficiency constitution and yang-deficiency constitution，qi-stagnation constitution and yang-deficiency constitution，qi-stagnation constitution and qi-deficiency constitution，and between yang-deficiency constitution and qi-deficiency constitution(P＞0.05).Comparison of FSH levels in patients with four constitution types showed that yin-deficiency constitution＞qi-stagnation constitution(P＜0.05)， yin-deficiency constitution＞yang-deficiency constitution (P＜0.05)， yin-deficiency constitution＞qi-deficiency constitution(P＜0.05)，and qi-stagnation constitution＞yang-deficiency constitution(P＜0.05).There was no significant difference in the comparison of FSH levels between qi-stagnation constitution and qi-deficiency constitution，and between yang-deficiency constitution and qi-deficiency constitution(P＞0.05).Conclusion：CM constitution types among 103 cases of premature ovarian failure patients in Wenzhou are mainly yin-deficiency constitution，followed by qi-stagnation constitution，qi-deficiency constitution and yang-deficiency constitution.The decrease of E2levels and increase of FSH levels in patients with yin-deficiency constitution are more obvious than those in patients with qi-stagnation constitution，yang-deficiency constitution and qi-deficiency constitution.