Objective：To observe the effect of Xiao'er Xiaozhi granules on intestinal absorption function of children with anorexia and the clinical effect in treating children anorexia.Methods：Divided 214 cases of patients randomly into the treatment group with 106 cases and the control group with 108 cases.The treatment group was given Xiao'er Xiaozhi granules for treatment，while the control group receivedgolden bifid.Both groups received treatment and follow-up for 2 weeks.Weight，height，urinary excretion rate of D-xylose before and after treatment were observed and compared，and the clinical effect was evaluated.Results：At the end and after 2 weeks of treatment，weight of patients in both groups was increased，weight gain in the treatment group was more than that in the control group，differences being significant(P＜ 0.01).No significant difference was found in the comparison of weight before，at the end and after 2 weeks of treatment between the two groups(P ＞ 0.05).However，changes of weight in the treatment group before，at the end and after 2 weeks of treatment were greater than those in the control group(P＜ 0.01).At the end of treatment，urinary excretion rate of D-xylose in both groups were increased when compared with those before treatment.In the follow-up after 2 weeks of treatment，urinary excretion rate of D-xylose in the treatment group were higher than those in the control group，differences being significant(P ＜ 0.01).At the end of treatment，in the follow-up after 2 weeks of treatment，the total effective rate in the treatment group was higher than that in the control group(P＜0.01).No adverse reaction was found in both groups during the treatment.Conclusion：Xiao'er Xiaozhi granules has good clinical effect on treating children anorexia.