Objective：To observe the clinical effect of chamomile gargle in treating recurrent aphthous ulcer.Methods：Selected 250 cases of patients with recurrent aphthous ulcer as study objects，and divided them into the observation group and the control group according to random table method，125 cases in each group.The observation group was given the therapy of chamomile gargle，while the control group receivedcompound gargle solution.Evaluated the clinical effect，and recorded the diameter of ulcer，pain，hematoma and effusion of the two groups before treatment and the third and fifth day of treatment.Results：The total effective rate was 96.8%in the observation group and was 82.4%in the control group，the difference being significant(P＜0.05).In the third and fifth day of the treatment，diameter of the ulcer of both groups was less than that before treatment(P ＜0.05)， visual analogue scale(VAS)scores of both groups were lower than those before treatment(P＜0.05).The diameter of the ulcer and VAS scores in the observation group were less and lower than those of the control group in the same period(P＜0.05).The hematoma scores and effusion scores in the third and fifth day of treatmnet in both groups were lower than those before treatment(P＜0.05).These two scores of the observation group were both lower than those of the control group in the same period(P＜0.05).Conclusion：Chamomile gargle can effectively improve the clinical effect of patients with recurrent aphthous ulcer，and its effect is better than that of compound gargle solution.