Objective：To observe the clinical effect of Haima Yizhi san combined with acupuncture for vascular dementia(VD).Methods：Divided 96 cases of VD patients into the treatment group and the control group randomly， 48 cases in each group.Both groups receivedthe routine therapy with western medicine for decompression and cranial nerve nourishment and received oral oxiracetam capsules simultaneously，while the treatment group additionally received Haima Yizhi san orally combined with Kaiqiao Xingnao acupuncture therapy.Course of treatment for both groups lasted for three months.Aftertreatment，evaluated clinical effect，observed improvement of cognitive function and activities of daily living(ADL)of patients，and detected the levels of brain-derived neurotrophic factor(BDNF)and vascular endothelial growth factor(VEGF)before and after treatment.Results：The total effective rate was 83.33%in the treatment group，being higher than 64.58%in the control group(P＜ 0.05).After treatment，scores of the mini-mental state examination(MMSE)and the Montreal cognitive assessment(MoCA)in both groups were increased when compared with those before treatment(P ＜ 0.05)，while the scores of the ADL were decreased when compared with those before treatment(P＜0.05).Increase of the scores of MMSE and VEGF in the treatment group was more significantly than that in the control group(P ＜ 0.05)，and decrease of ADL scores was more significantly than that in the control group(P ＜ 0.05).After treatment，levels of serum BDNF and VEGF in both groups were higher than those before treatment(P ＜ 0.05)；levels of serum BDNF and VEGF in the treatment group were higher than those in the control group(P＜0.05).Conclusion：Additional application of Haima Yizhi san combined with acupuncture based on routine western medicine can effectively improve the dementia syndromes，memory and cognitive function and ADL，and promote cranial nerve nourishment for the treatment of VD.