Objective：To observe the clinical effect of Anshen Dingzhi prescription combined with western medicine for hypertension with primary insomnia.Methods：Divided 108 cases of patients of hypertension with primary insomnia into the control group and the observation group randomly.Both groups receivedhypotensor for treatment，while the observation group additionally received Anshen Dingzhi prescription.The course of treatment for both groups lasted for a month.After treatment， evaluated improvement of sleep， observed changes of scores of pittsburgh sleep quality index(PSQI)， blood pressure as well as myocardial function indexes including serum cardiac troponin T(cTnT)and delta diameter/delta time(dD/dt)before and after treatment.Cardiovascular events in both groups were collected 3 months after treatment.Results：After treatment，improvement of sleep in the observation group was better than that in the control group(P＜ 0.05).PSQI scores，systolic pressure，diastolic pressure，and levels of cTnT and dD/dt in both groups were lower than those before treatment(P＜ 0.05，P＜ 0.01).PSQI scores，systolic pressure，diastolic pressure，and levels of cTnT and dD/dt in the observation group were lower than those in the control group(P＜0.05，P＜ 0.01).Three months after treatment，the incidence of cardiovascular events in the observation group was lower than that of the control group(P＜0.05).Conclusion：Anshen Dingzhi prescription combined with western medicine for hypertension with primary insomnia can improve sleep，control blood pressure，enhance myocardial function and decrease the incidence of cardiovascular events after treatment.