Objective：To observe the effect of the therapy of feeling pulse with Zhouyi Xiangshu on skin temperature of five-shu point on spleen and stomach meridian and ghrelin in patients with functional dyspepsia.Methods：Divided 160 cases of patients with functional dyspepsia into 2 groups randomly，80 cases in each group.The treatment group receivedthe therapy of feeling pulse with Zhouyi Xiangshu，while the control group was treated with mosapride citrate dispersible tablets.Detected skin temperature of five-shu point on spleen and stomach meridian and serum ghrelin content before treatment and on the 7th， 14thand 21stday of treatment.Discussed the correlation between the two indexes as well.Results： Before treatment，no significant difference was found in the comparison of skin temperature of five-shu point on spleen and stomach meridian between the two groups(P＞0.05).On the 14thday of treatment，skin temperature of Yinbai and Yinlingquan in the treatment group was higher than that before treatment and that in the control group，differences being significant(P＜0.05).On the 21stday of treatment，skin temperature of five-shu point on both spleen and stomach meridian was increased in the treatment group，while that in the control group was decreased when compared with that before treatment，differences being significant(P＜0.05).The skin temperature of five-shu point on both spleen and stomach meridian in the treatment group was higher than that in the control group(P＜0.05).After treatment，serum ghrelin content in both groups was increased when compared with that before treatment，differences being significant(P＜0.05).No significant difference was found in the comparison of serum ghrelin content at the same time in both groups(P＞0.05).Serum ghrelin content was found to be positively correlated with skin temperature of five-shu point on spleen and stomach meridian(P=0.003).Conclusion：By regulating the unbalance of meridian qi in spleen and stomach，the therapy of feeling pulse with Zhouyi Xiangshu can increase the skin temperature of five-shu point on spleen and stomach meridian so as to improve the function of spleen and stomach.The mechanism of this therapy may be related to serum ghrelin content.