Objective：To analyze correlation of Chinese medicine syndrome with coagulation and fibrinolysis indexes of patients with chronic obstructive pulmonary disease.Methods：According to the difference of Chinese medicine syndrome，divided 150 patients with chronic obstructive pulmonary disease into phlegm-heat obstructing lung group，lung and spleen deficiency group as well as lung and kidney deficiency group，50 cases in each group.50 healthy people were selected as the control group in the meanwhile.Detected levelsof D-Dimer in blood， activated partial thromboplastin time(aPTT)，prothrombin time(PT)and fibrinogen(Fbg)and evaluated pulmonary function grade of patients.Results：Pulmonary function of phlegm-heat obstructing lung group was the best in the three groups，while pulmonary function of lung and spleen deficiency group was the worst.The comparisons of pulmonary function of patients among the three groups showed differences(P＜0.01).Levels of PT，aPTT in the case group were lower than those in the control group(P＜0.01).Levels of Fbg and D-D in the case group were higher than those in the control group(P＜0.01).Levels of PT，aPTT in phlegm-heat obstructing lung group were higher than those in lung and kidney deficiency group and lung and spleen deficiency group(P＜0.05).Levels of Fbg and D-D in phlegm-heat obstructing lung group were lower than those in lung and kidney deficiency group and lung and spleen deficiency group(P＜0.05).Levels of PT，aPTT in lung and kidney deficiency group were higher than those in lung and spleen deficiency group(P＜0.05).Levels of Fbg and D-D in lung and kidney deficiency group were lower than those in lung and spleen deficiency group(P＜0.05).There was a negative correlation between PT，aPTT and phlegm-heat obstructing lung，lung and kidney deficiency，and lung and spleen deficiency syndromes types(P＜0.01).There was a positive correlation between levelsof Fbg，D-D and phlegm-heat obstructing lung，lung and kidney deficiency，and lung and spleen deficiency syndromes types(P＜0.05，P＜0.01).Conclusion：There is a significant correlation of Chinese medicine syndrome with coagulation and fibrinolysis indexes ofpatients with chronic obstructive pulmonary disease.Coagulation andfibrinolysis indexes can be auxiliary indexes to speculate Chinese medicine syndrome of patients with chronic obstructive pulmonary disease.