Objective：To observe the clinical effect of Jianpi Qushi prescription combined with metformin hydrochloride tablets for obese type 2 diabetes mellitus(T2DM)as well as its effect onserum lipids，blood glucose and islet function of patients.Methods：Divided 80 cases of patients with obese T2DM into the control group and the treatment group randomly，40 cases in each group.Both groups were given metformin hydrochloride tablets for treatment，while the treatment group additionally receivedJianpi Qushi prescription.Observed improvements of clinical symptoms，serum lipids，blood glucose，and islet function before and after treatment.Compared the clinical effect of both groups.Results：The total effective rate was 62.5%in the control group and was 87.5% in the treatment group，the difference being significant(P＜0.05).Aftertreatment，scores of thirst，polyorexia，frequent urination and polyuria，languid shortness of breath with a disinclination to talk，heaviness in head and body，and limb numbness in treatment group were all decreased when compared with those before treatment(P＜0.05).The above 7 Chinese medicine syndrome scores in the treatment group were lower than those in the control group(P ＜0.05).After treatment， levels of total cholesterol(TC)， triglycerides(TG)and low density lipoprotein cholesterol(LDL-C)as well as body mass index(BMI)were decreased when compared with those before treatment(P＜0.05).Levels of high density lipoprotein cholesterol(HDL-C)were increased when compared with those before treatment(P＜0.05).Levels of TC and TG as well as BMI in the treatment group were lower than those in the control group(P＜0.05).HDL-C levels in the treatment group were higher than those in the control group(P＜0.05).After treatment，levels of glycosylated hemoglobin(HbA1c)，fasting plasma glucose(FBG)，postprandial 2h plasma glucose(P2hBG)and fasting insulin(FINS)as well as Homeostasis model assessment-insulin resistance(HOMA-IR)values in both groups were decreased when compared with those before treatment(P＜0.05).Levels of HbA1c，FPG，P2hBG and FINS as well as HOMA-IR values in the treatment group were all lower than those in the control group(P＜0.05).After treatment，levels of glucose-dependent insulinotropic poly peptide(GIP)and glucagon-like peptide-1(GLP-1)in both groups were increased when compared with those before treatment(P＜0.05).Levels of GIP and GLP-1 in the treatment group were both higher than those in the control group(P＜0.05).Conclusion：The therapy of Jianpi Qushi prescription combined with metformin hydrochloride tablets can effectively improve the clinical symptoms of patients with obese T2DM，which has significant effect on decreasing blood glucose indexes，improving serum lipids and promoting the formation of incretin GIP and GLP-1.