To observe the clinical effect of Paishi tang combined with western medicine for renal calculi.Methods：Selected 110 cases of patients with renal calculi and divided them into the control group and the observation group randomly，55 cases in each group.Both groups receivedroutine western medicine for treatment，while the observation group additionally received Paishi tang.Evaluated the curative effect and observed changes of levels of serum creatinine and blood urea nitrogen before and after treatment in both groups.Results：Before treatment，no significant difference was found in the comparison of levels of serum creatinine and blood urea nitrogen between the two groups(P＞0.05).After treatment，levels of serum creatinine and blood urea nitrogen in both groups were lower than those before treatment，differences being significant(P＜0.05).Levels of serum creatinine and blood urea nitrogen in the observation group were lower than those in the control group，differences being significant(P＜0.05).The total effective rate was 76.4%in the control group and was 90.9%in the observation group，the difference being significant(P＜0.05).Conclusion：Based on routine treatment with westernmedicine，applying Paishi tang for renal calculi can improve the clinical effect.