objective：To observe the clinical effect of thunder-fire moxibustion combined with local external application of tobramycin dexamethasone eye drops for meibomain gland dysfunction.Methods：Divided 60 patients with meibomain gland dysfunction into the control group and the observation group randomly according to random number table，30 cases in each group.Both groups receivedlocal application of tobramycin dexamethasone eye drops for treatment，while the observation group additionally received thunder-fire moxibustion.Course of treatment for both groups lasted for 14 days.Results：After treatment，scores of subjective symptoms and palpebral margin in both groups were decreased when compared with thosebefore treatment，differences being significant(P＜0.05).After treatment，scores of subjective symptoms and palpebral margin in the observation group were lower than those in the control group，differences being significant(P＜0.05).After treatment，tear break-up time in both groups were increased when compared with that before treatment，and character score of palpebral margin secretion in both groups were decreased when compared with those before treatment，differences being significant(P＜0.05).After treatment，tear break-up time in the observation group was higher than that in the control group，and character score of palpebral margin secretion in the observation group was lower than that in the control group，differences being significant(P＜0.05).After treatment，no significant difference was found in the comparison of intraocular pressure between the two groups(P＞0.05).Conclusion：Thunder-fire moxibustion combined with local application of tobramycin dexamethasone eye drops has significant clinical effect in treating meibomain gland dysfunction，which is worth of clinical application.