Objective：To observe the clinical effect of Kangai injection combined with the therapy of mitoxantrone and cytosine arabinoside(MA)as well as the pure MA therapy for acute myeloid leukemia.Methods：Divided 82 cases of patients who were included in observation with acute myeloid leukemia into the combination group and the control group randomly.The control group was simply given the MA therapy，while the combination group additionally receivedKangai injection therapy.Observed the total clinical effect after 2 courses of treatment.Observed and compared the minimum leukocyte，the recovery time of leukocyte，myelosuppression，gastrointestinal reaction，infection，and the incidence of all-cause mortality in both groups.Results：The total effective rate was 80.95%in the combination group and 60.00%in the control group，the difference being significant(P＜ 0.05).Compared the hemograms in myelosuppression period of both groups.After treatment，respectively compared the minimum leukocyte and the recovery time of leukocyte between the two groups，differences being significant(P＜0.01).The combination group was superior to the control group.Compared the incidence of gastrointestinal reaction and myelosuppression in both groups respectively，differences being significant(P＜0.01).Compared the incidence of infection and all-cause mortality rate between the two groups，there being no significance in differences(P＞0.05).Conclusion：The application of Kangai injection combined with the therapy of mitoxantrone and cytosine arabinoside can effectively relive the clinical symptoms of patients with acute myeloid leukemia，and reduce the incidence of gastrointestinal reaction and myelosuppression.