补益肺肾、化瘀解毒法治疗去势抵抗性前列腺癌临床研究
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R737.25

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江苏省中医药局重点科技项目(ZD201503)


Clinical Study of Therapy of Tonifying Lung and Kidney Combined with Resolving Stasis and Detoxification for Castrated Resistant Prostate Cancer
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    摘要:

    目的:观察补益肺肾、化瘀解毒方联合内分泌疗法治疗去势抵抗性前列腺癌的临床疗效。方法:将符合纳入标准的72例患者随机分为2组。对照组采用单纯西医治疗,最大限度雄激素阻断疗法(MAB);治疗组在对照组治疗方案的基础上加用补益肺肾、化瘀解毒方治疗,疗程均为3月。观察2组治疗前后总生存期、血清前列腺特异性抗原(PSA)、体力状况、生活质量和中医症状评分的变化。结果:治疗后,对照组患者血清PSA有明显上升,Karnofsky评分降低,各方面生活质量评分均有所下降,中医症状评分升高,治疗前后比较,差异均有统计学意义(P<0.05)。而治疗组患者PSA与治疗前比较,上升不明显,差异无统计学意义(P>0.05),且与对照组比较,低于对照组,差异有统计学意义(P<0.05)。治疗组Karnofsky评分明显升高,各方面生活质量评分均有改善,中医症状评分降低,差异均有统计学意义(P<0.05);且以上各项包括Karnofsky评分、生活质量评分、中医症状评分等分别与对照组比较,差异均有统计学意义(P<0.05)。治疗组患者死亡13例,平均生存期24.1月;对照组患者死亡15例,平均生存期19.7月。结论:中药补益肺肾、化瘀解毒方治疗去势抵抗性前列腺癌可减少西医治疗的副作用,稳定PSA水平,改善患者生活质量,进而延长患者总生存期。

    Abstract:

    Objective: To observe the clinical effect of the prescription of tonifying lung and kidney combined with resolving stasis and detoxification combined with endocrine therapy for castrated resistant prostate cancer.Methods:Divided 72 cases of patients with castrated resistant prostate cancer according with the inclusion criteria into the control group and the treatment group randomly.Both groups receivedwestern medicine therapy of maximal androgen blockade(MAB),while the treatment group additionally received the prescription of tonifying lung and kidney combined with resolving stasis and detoxification.The course of treatment for both groups lasted for 3 months.Observed changes of overall survival,serum prostate specific antigen(PSA),physical status,life quality and Chinese medicine symptom scores before and after treatment in both groups.Results: After treatment, in the control group, serum PSA levels were increased obviously, scores of Karnofsky and each aspect of life quality were decreased,as well as Chinese medicine symptom scores were increased,compared with those before treatment,differences being significant(P<0.05).Serum PSA levels in the treatment group were not significantly increased,comparing with those before treatment,there was no significance in differences(P>0.05).Serum PSA levels in the treatment group were lower than those in the control group,the difference being significant(P<0.05).Karnofsky scores were increased obviously,scores of each aspect of life quality were improved,and Chinese medicine symptom scores in the treatment group were decreased, comparing with those before treatment, differences being significant(P<0.05).The comparisons of the above scores between the two groups showed significance in differences(P<0.05).The number of death cases was 13 and the average survival was 24.1 months in the treatment group,while the number of death cases was 15 and the average survival was 19.7 months in the control group.Conclusion:Chinese medicine therapy of tonifying lung and kidney prescription as well as resolving stasis and detoxification prescription for castrated resistant prostate cancer can reduce side effect of western medicine therapy,stabilize PSA level and improve life quality of patients so as to prolong overall survival of patients.

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卢子杰,雷博涵,张扬,章茂森,朱清毅,王省博,徐福松.补益肺肾、化瘀解毒法治疗去势抵抗性前列腺癌临床研究[J].新中医,2018,50(1):91-94

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  • 在线发布日期: 2018-01-05
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