Objective： To observe the effect of Lanqin granules on changes of inflammatory factors of patients with periodontitis.Methods：Averagely divided 108 cases of patients with periodontitis in observation into two groups randomly，and 54 healthy adults were selected as the normal group.Both groups receivedthe treatment of rinsing the oral cavity with gargle，while the observation group additionally received Lanqin granules.Observed and compared the periodontal health indexes such as periodontal depth(PD)， clinical attachment level(AL)， bleeding index(BI)and plague index(PLI)as well as bleeding on probing(BOP)，and the levels of inflammatory factors，C-reactive protein(CRP)and interleukin-6(IL-6).Results：After the treatment，PD，AL，BI，PLI and BOP were compared with those before treatment，differences being significant(P＜ 0.05).All the clinical indicators PD，AL，BI，PLI and BOP in both groups were compared，differences being significant(P＜ 0.05).After the treatment，CRP and IL-6 in both groups were decreased when comparing with those before treatment，differences being significant(P＜ 0.05)；decrease of levels of inflammatory factors in the observation group were more significant when comparing with those of the control group，differences being significant(P＜ 0.05)；compared with the normal group，there was no significance being found in the differences(P＞ 0.05).Conclusion：Lanqin granules can reduce the levels of inflammatory factors of patients with periodontitis，and help control the inflammation of periodontitis.