Objective： To observe the effectof Chaihu Shugan powder on bile components in patients with choledocholithiasis after endoscopic retrograde cholangiopancreatography(ERCP).Methods：Selected 60 cases of patients with choledocholithiasis of qi depression of liver-gallbladder type，and divided them randomly into 2 groups，30 cases in each group.The control group receivedERCP lithotomy，while the treatment group was given ERCP lithotomy combined with Chinese medicine treatment of Chaihu Shugan powder.Took bile from nasobiliary drainage during operation and on the 3rd and 7thday after operation.Detected the activity of β-glucuronidase(β-Gase)and changes of levels of total bile acid(TBA)，total bilirubin(TBil)，direct bilirubin(DBil)，and calcium ion(Ca2+).Results：The comparison of bile components on the 3rdand 7thday after operation with those during operation showed that TBA content in both groups was increased，while levels of β-Gase，TBil，DBil，and Ca2+were decreased，differences being significant(P＜ 0.01).On the 7thday after operation，TBA content in the treatment group was significantly increased when compared with that in the control group，while levels of β-Gase，TBil，DBil，and Ca2+were significantly decreased when compared with those in the control group，differences being significant(P＜0.01).Conclusion：Chaihu Shugan powder can improve bile components in patients with choledocholithiasis after ERCP，so as to effectively prevent the recurrence of stones.