Objective：To observe the clinical effect of Fuzheng Jiedu tang in preventing and treating myelosuppression of postoperative breast cancer during peri-operative chemotherapy period.Methods：Divided 116 cases of patients with postoperative breast cancer during peri-operative chemotherapy period into the control group and the observation group randomly，58 cases in each group.Both groups were given centrifugation extractable fluid(CEF)therapy after operation，while the observation group was additionally given Fuzheng Jiedu tang for treatment for 3 weeks as one course，3 courses continuously.Recorded the incidence and occurrence of myelosuppression，analyzed the time of occurrence and recovery，and monitored levels of white blood cell count(WBC)，blood platelet count(BPC)and hemoglobin(Hb)in serum after chemotherapy.Results：The incidence of myelosuppression was 13.8%in the observation group and 51.7%in the control group，the difference being significant(P＜0.05).The occurrence time of myelosuppression in the observation group was later than that in the control group，while the recovery time of myelosuppression was earlier than that in the control group，differences being significant(P＜0.05).After chemotherapy，the content of WBC，BPC and Hb in the observation group were increased when compared with those in the control group，differences being significant(P＜0.05).The incidence of adverse reaction such as infection and hemorrhage after chemotherapy was 19.0%in the observation group，being lower than that of 31.0%in the control group，differences being significant(P＜ 0.05).Conclusion：The application of Fuzheng Jiedu tang in preventing and treating myelosuppression of postoperative breast cancer during peri-operative chemotherapy period has outstanding effects.It can obviously reduce the degree of myelosuppression，delay the occurrence time，promote recovery，and lower the incidence of adverse reactions such as infection and hemorrhage.Therefore，it is worth being applied in clinical application.