Objective：To observe the effect of Qingfei mixture on immune function in patients with advanced non-small cell lung cancer with chemotherapy.Methods：Divided 82 cases of patients with advanced non-small cell lung cancer into observation group and the control group，41 casesin each group.The control group receivedconventional dose chemotherapy，while the observation group was additionally given Qingfei mixture as treatment for 8 weeks based on chemotherapy.Detected the changes of T-lymphocyte subsets(CD3+，CD4+，CD8+，CD4+/CD8+)，natural killer(NK)，serum immune globulin(IgA，IgG，IgM)in two groups.Evaluated the solid tumor size with CT.Results：After treatment，the total effective rate for curative effect of solid tumor was 68.29%in the observation group，being higher than 43.90%in the control group(P＜0.05).CD8+levels in the control group were decreased when compared with those before treatment(P＜0.05)，while no significant difference being found in other indexes when compared with before treatment(P＜ 0.05).The levels of NK，CD3+，CD4+，CD4+/CD8+in the observation group were increased when compared with those before treatment(P＜ 0.05)and were higher than those in the control group(P＜0.05).The levels of CD8+were decreased when compared with those before treatment(P＜0.05)，and were lower than those in the control group(P＜0.05).The levels of IgG，IgA，IgM were increased in the observation group when compared with those before treatment(P＜0.05)and were higher than those in the control group(P＜ 0.05).Conclusion：Based on chemotherapy，additional application of Qingfei mixture in treating advanced toxic heat flourishing type patients with NSCLC can improve the curative effect and immune function of the patients.