Objective： To observe the effect of transcutaneous acupoint electric stimulation combined with generalanesthesia on perioperative hemodynamics and immune function of the senile patients with craniotomy evacuation of hematoma.Methods：Divided 60 study objects into two groups randomly，30 cases in each group.Both groups receivedthe equivalent intravenous injection of penehyclidine hydrochoride，midazolam，propofol，fentanyl and cisatracurium besilate to conduct anaesthesia and maintain bispectral index(BIS)in 40～60 during operation.The observation group received the transcutaneous acupoint electric stimulation at bilateral Zusanli(ST 36)and Liangqiu(ST 34)before anesthesia.Compared mean arterial pressure(MAP)and the levels of heart rate(HR)of the two groups before anaesthesia induction，5 min after anaesthesia induction，during skin incision，1h after skin incision，immediately after operation and 30 min after operation；collected venous blood samples at various time points of preoperation so as to detect levels of natural killer(NK)cells，CD4+，CD8+and CD4+/CD8+and make analysis statistically.Results：In intragroup comparation，HR of the observation group was increased during skin incision，MAP and HR of the control group were both increased 5 min after anaesthesia induction and during skin incision when compared with those before anaesthesia induction.Comparing with the control group，MAP and HR of the observation group were both increased 5 min after anaesthesia induction and during skin incision，differences being significant(P＜0.05).In intragroup comparation，the levels of NK，CD4+，CD8+and CD4+/CD8+in both groups were decreased 1 h after skin incision and 30 min after operation when compared with those before anaesthesia induction，differences being significant(P＜0.05)；comparing with the control group，the levels of NK，CD4+and CD4+/CD8+in the observation group were decreased while the level of CD8+was increased 1 h after skin incision and 30 min after operation，differences being significant(P＜0.05).The adverse reaction rate in both group was compared，there being no significance in the difference(P ＞0.05).Conclusion：The perioperative hemodynamics of transcutaneous acupoint electric stimulation combined with general anesthesia in the treatment of the senile patients with craniotomy evacuation of hematoma is stable and safe，which helps enhance immune function.