Objective：To observe the awakening effect of Chinese medicine characteristics awakening therapy and nursing for coma patients with hypertensive intracerebral hemorrhage(HICH)after craniotomy.Methods：Selected 80 cases of coma patients with HICH after craniotomy admitted in our hospital，and divided them into the observation group and the control group randomly，40 cases in each group.Both groups receivedroutine treatment and nursing，while the observation group additionally received Chinese medicine characteristics awakening therapy and nursing.Made an intergroup comparison of score of Glasgow coma scale(GCS)，blood flow velocity in internal carotid artery(ICA)and middle cerebral artery(MCA)，score of national institute of health stroke scale(NIHSS)， Bartherl index，and changes of content of 5-hydroxytryptamine(5-TH)in cerebrospinal fluid，dopamin(DA)，norepinephrine(NE)and acetylcholine(ACh)before and after intervention.Recorded Glasgow outcome scale during follow-up.Results：After intervention，GCS scores in both groups were increased when compared with those before intervention(P＜ 0.05)；GCS scores in the observation group were higher than those in the control group(P＜0.05).GCS scores in the observation group during follow-up were higher than those in the control group(P＜0.05).Afterintervention，blood flow velocity in MCA and ICA in both groups was slower than that before intervention(P＜ 0.05)；blood flow velocity in MCA and ICA of the observation group was both lower than that of the control group(P＜0.05).After intervention，5-TH content in both groups was lower than that before intervention(P＜ 0.05)，and content of DA，NE and ACh was higher than that before intervention(P＜0.05).5-TH content in the observation group was lower than that in the control group(P＜ 0.05)，and content of DA，NE and ACh was higher than that in the control group(P＜ 0.05).After intervention，comparing with those before intervention，NIHSS scores in both groups were reduced(P＜ 0.05)，and Bartherl indexes in both groups were increased(P＜0.05).After intervention，NIHSS scores in the observation group were lower than those in the control group(P＜ 0.05)，and Bartherl indexes in the observation group were higher than those in the control group(P＜0.05).Conclusion：Chinese medicine characteristics awakening therapy and nursing intervention for coma patients with HICH after craniotomy has significant awakening effect.The mechanism may be related to the promotion of nerve function recovery，improvement of cerebral blood flow velocity and regulation of relevant neurotransmitter release.