ObjectiveTo observe the clinical effect of Tongxinluo capsules combined with clopidogrel hydrogensulfate tablets on the basis of routine therapy for unstable angina pectoris.MethodsDivided 90 cases of patients with unstable angina pectoris of qi deficiency and blood stasis syndrome into the observation group and the control group randomly，45 cases in each group.Both groups were given routine therapy and clopidogrel hydrogensulfate tablets for treatment，while the observation group was additionally receivedTongxinluo capsules.Both groups received treatment for 3 weeks.Compared clinical effect of both groups after treatment， and detected indexes of serum lipids which include total cholesterol(TC)，triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)as well as expression levels of atherosclerosis adhesion molecules which include vascular cell adhesion molecule-1(VCAM-1)and intercellular adhesion molecule-1(ICAM-1)of patients in both groups before and after treatment.ResultsAfter 3 weeks of treatment，the total effective rate of the observation group was higher than that of the control group，the difference being significant(P＜0.05).Levels of TC，TG，LDL-C，VCAM-1 and ICAM-1 of both groups were lower than those before treatment(P＜ 0.05)；all index values in the observation group were lower than those in the control group，differences being significant(P＜0.05).ConclusionTongxinluo capsules combined with clopidogrel hydrogensulfate tablets on the basis of routine therapy can obviously decrease serum lipids indexes and levels of atherosclerosis adhesion molecules，effectively resist thrombosis，inhibit platelet aggregation so as to improve body microcirculation and recover myocardial function in treating unstable angina pectoris of qi deficiency andblood stasis syndrome type，which has significant effect on myocardial oxygen delivery and improvement of vascular endothelial function.