ObjectiveTo observe the curative effect of integrated Chinese and western medicine therapy in treating patients with shoulder-hand syndrome of post-ischemic stroke with syndrome of wind-phlegm stasis.MethodsDivided 90 cases of patients with shoulder-hand syndrome of post-ischemic stroke with syndrome of wind-phlegm stasis into the treatment group and the control group randomly，45 cases in each group.The control group was given routine therapy and recovery intervention measures of modern internal medicine，while the treatment group additionally receivedacupuncture combined with oral administration of modified Huatan Tongluo tang.Treatment course of both groups lasted for 4 weeks.Compared the shoulder-hand syndrome scale score，score of wind-phlegm stasis syndrome which includes light-headedness，abundant sputum，dysphasia and hypoesthesia，and calcitonin gene-related peptide(CGRP)level in both groups before and after treatment as well as clinical curative effect at the end of the course.ResultsAfter treatment，the total effective rate was 91.11%in the treatment group and 71.11%in the control group，the difference being significant(P＜0.05).Scores of sensory，motor，and autonomic nerve in shoulder-hand syndrome scale，and light-headedness，abundant sputum，dysphasia，and hypoesthesia in both groups were declined when compared with those before treatment(P ＜ 0.01)，while scores of the above indexes in the treatment group were lower than those in the control group(P＜0.01).CGRP levels in serum in both groups were increased when compared with those before treatment(P＜0.01).In the second and fourth week of treatment，CGRP levels in serum of the treatment group were higher than those of the control group(P ＜ 0.01).ConclusionBased on routine western medicine therapy and rehabilitation training，combination of acupuncture and integrated Chinese and western medicine therapy with modified Huatan Tongluo tang can promote rehabilitation of patients withshoulder-hand syndrome of wind-phlegm stasis type，and its function of regulating CGRP level in serum may contribute to the curative effect.