ObjectiveTo observe the clinical effect of integrated therapy of Chinese medicine comprehensive therapycombined with western medicine in treating senile patients with chronic functional constipation.MethodsDivided 150 cases of senile patients with chronic functional constipation of spleen-kidney yang deficiency type into the treatment group and the control group randomly，75 cases in each group.Both groups receiveddomperidone tablets and phenolphthalein tablets for treatment，while the treatment group additionally received integrated therapy of Chinese medicine comprehensive therapy，including oral application of Wenshen Runchang prescription as well as acupoint application with Radix et Rhizoma Rhei at Shenque and performing acupuncture.Both groups received the treatment for 1 month.Compared scores of main symptoms[difficult defecation，defecation time，fecal properties，abdominal distension，times of defecation]，and the changes of level of serum substance P(SP)and vasoactive intestinal peptide(VIP)before and after treatment，and clinical effect of both groups.ResultsAfter treatment，the total effective rate was 97.33%in the treatment group and 86.67%in the control group，the difference being significant(P ＜ 0.05).Scores of main symptoms[difficult defecation，defecation time，fecal properties，abdominal distension，times of defecation]in both groups were lower than those before treatment(P ＜ 0.01)；the main symptoms scores in the treatment group were all lower than those in the control group(P＜0.01).Serum SP levels in both groups were higher than those before treatment，and VIP levels were lower than those before treatment，differences being significant(P ＜ 0.01)；serum SP levels in the treatment group were higher than those in the control group(P ＜ 0.01)，and VIP levels were lower than those in the control group(P＜0.01).ConclusionIntegrated therapy of Chinese medicine comprehensive therapy combined with western medicine has certain curative effect in treating senile patients with chronic functional constipation，and one of the reasons may be its effect of raising serum SP level and reducing VIP level.