Objective：To observe the clinical effect of Yishen Yangyin Tongluo prescription for type 2 diabetes nephropathy of Qi-yin deficiency type at stage III.MethodsDivided 80 cases of inpatients and outpatients into the control group and the treatment group randomly，40 cases in each group.Both groups receivedwestern medicine for antihypertation and lowering blood glucose，while the treatment group additionally received modified Yishen Yangyin Tongluo prescription，12 weeks as one course.After both groups received one course for treatment，observed changes of clinical symptoms，urinary albumin excretion rate(UAER)，glycosylated hemoglobin(HbA1c)，C reactive protein(CRP)，urinary albumin in 24 h(TP/24 h)and renal function of patients in both groups.ResultsThe total effective rate was 72.5%in the treatment group and was 35.0%in the control group，the difference being significant(P＜0.05).After treatment，the comparison of Chinese medicine syndrome scores between the two groups showed significance in differences(P＜0.05).Compared TP/24 h，UAER，creatinine(Cr)and CRP in the treatment group before and after treatment，differences were significant(P＜0.05).Compared TP/24 h，UAER，Cr and CRP between the two groups，differences showed significant(P＜0.05).No significant difference was found in the comparison of HbA1c of the two groups before and after treatment and the comparison of HbA1c after treatment between the two groups(P＞0.05).ConclusionYishen Yangyin Tongluo prescription can effectively reduce urine protein of patients with type 2 diabetes nephropathy of qi-yin deficiency type at stageⅢand improve clinical symptom of patients.