Objective：To observe the clinical effect of Zuogui pills combined with western medicine for lupus nephritis with yin deficiency of liver and kidney syndrome.MethodsDivided 88 patients with hormone for lupus nephritis with yin deficiency of liver and kidney syndrome into the treatment group and the control group randomly，44 cases in each group.Both groups were treated with methylprednisolone tablets and cyclophosphamide for injection，while the treatment group was additionally given modified Zuogui pills.Both groups continuously receivedtreatment for 6 months.Compared clinical effect of patients in both groups.Evaluated scores of lupus erythematosus activity and symptoms scores of yin deficiency of liver and kidney syndrome of patients in both groups before and after treatment.Detected levels of interleukin(IL)-17 in serum and urine of patients in both groups.ResultsThe total effective rate was 97.73%in the treatment group and 81.82%in the control group，the difference being significant(P ＜ 0.05).In the third and sixth month after treatment，scores of lupus erythematosus activity and symptoms scores of yin deficiency of liver and kidney syndrome such as dropsy，dry mouth and throat，hair loss，tinnitus and burning sensation of five feverish centers in both groups were decreased when compared with those before treatment(P＜0.01).Scores of lupus erythematosus activity and all symptoms in the treatment group were lower than those in the control group(P＜0.01).Levels of IL-17 in serum and urine in both groups were decreased when compared with those before treatment(P＜0.01).Levels of IL-17 in serum and urine in the treatment group were lower than those in the control group(P＜0.01).ConclusionModified Zuogui pills combined with western medicinefor lupus nephritis with yin deficiency of liver and kidney syndrome can control disease，improve clinical symptoms and the clinical effect.The mechanism may be related to reducing the expression of inflammatory factor IL-17 so as to relieve immunologic injury of body.