ObjectiveTo observe the clinical effect of Bushen Zhuanggu tang combined with vertebroplasty for senile osteoporotic thoracolumbar vertebral compression fractures.MethodsDivided 60 cases of senile patients with osteoporotic thoracolumbar vertebral compression fractures enrolled in the observation into two groups randomly，30 cases in each group.Both groups receivedvertebroplasty，while the study group additionally received Bushen Zhuanggu tang orally.Observed Cobb angle，pain degree，bone mineral density，anterior vertebral height and intermediate vertebral height in both groups，and compared the clinical effect in both groups.ResultsAfter treatment，Cobb angles in both groups were evidently smaller than those before treatment，scores of visual analogue scale(VAS)in both groups were significantly lower than those before treatment， and bone mineral density， anterior vertebral height and intermediate vertebral height in both groups were obviously higher than those before treatment，differences being significant(P＜ 0.05，P＜ 0.01).Respectively compared the above indexes in the study group after treatment with those in the control group，differences being significant(P＜0.05，P＜0.01).The results indicated that the treatment in both group could improve Cobb angle，VAS scores，bone mineral density value，anterior vertebral height and intermediate vertebral height，and the study group was better than the control group.The total effective rate was 80.00%in the study group and 63.33%in the control group，the difference being significant(P＜0.05).ConclusionBushen Zhuanggu tang combined with vertebroplasty for senile osteoporotic thoracolumbar vertebral compression fractures can improve scoliosis severity，increase bone mineral density and vertebal heights，and release the pain of patients with good clinical effect and applicable value.