ObjectiveTo observe the clinical effect and safety of Yanghe tang combined with ultrasound-guided Mammotome minimally invasive surgery for benign breast mass.MethodsSelected 329 cases of patients with benign breast mass，and divided them into the control group(172 cases)and the research group(157 cases)according to different treatment.The control group receivedconventional operative treatment，while the research group was given Mammotome minimally invasive surgery combined with Yanghe tang.Compared the scores of clinical effect，satisfaction of patients，visual analogue scales(VAS)of pain and its safety between the two groups.ResultsIn the research group，the amount of intraoperative blood loss was less than that in the control group，the operation time was shorter than that in the control group，VAS scores were higher than those in the control group on the first day after operation，and satisfaction scores were higher than those in the control group，differences all being significant(P＜0.05).The respective comparisons of the incidence of mammary morphological changes，intramammary hematoma and other complications between the two groups showed significance in differences(P＜0.05).There was no significant difference being found in the incidence of incision infection，subcutaneous ecehymosis and other complications when compared to those in the control group(P ＞ 0.05).Conclusions：The therapy of Yanghe tang combined with ultrasound-guided Mammotome minimally invasive surgery for benign breast mass has good clinical effect.It has such advantages as higher satisfaction of patients，less postoperative pain，and less changes of breast shape.