Objective：To observe the clinical effect of acupuncture therapy of strengthening spleen and soothing liver for diarrhea-predominant irritable bowel syndrome(IBS-D)with liver-qi attacking spleen syndrome.MethodsDivided 110 cases of patients with IBS-D liver-qi attacking spleen syndrome into the control group and the observation group randomly，55 cases in each group.The control group receivedpinaverium bromide tablets combined with live combined bifidobacterium，lactobacillusand enterococcuspowder for treatment，while the observation group received acupuncture therapy of strengthening spleen and soothing liver.After treatment，evaluated the clinical effect，and observed changes of scores of IBS symptom severity scale(IBS-SSS)，IBS quality of life(IBS-QOL)and liver-qi attacking spleen syndrome before and after treatment in both groups，as well as recorded recurrence rate.ResultsThe total effective rate was 72.00%in the control group and was 90.74%in the treatment group，the difference being significant(P ＜ 0.05).After treatment，scores of IBS-SSS and liver-qi attacking spleen syndrome in both groups were decreased when compared with those before treatment(P＜0.01).Scores of IBS-QOL were increased when compared with those before treatment(P＜0.01).Scores of IBS-SSS and liver-qi attacking spleen syndrome in the observation group were lower than those in the control group(P＜0.01).Scores of IBS-QOL in the observation group were higher than those in the control group(P ＜ 0.01).After treatment，daily defecation frequency and days of urgent defecation in 10 days in both groups were decreased when compared with those before treatment(P＜0.01).Daily defecation frequency and days of urgent defecation in 10 days in the observation group were less than those in the control group(P＜0.01).In the 3 months of follow-up，there were 22 recurrence cases in the observation group with the recurrence rate being 44.90%(22/49)，and 23 recurrence cases in the control group with the recurrence rate being 63.89%(23/36)，the difference was not statistically significant(P＞0.05).ConclusionAcupuncture therapy of strengthening spleen and soothing liver for IBS-D with liver-qi attacking spleen syndrome can relieve clinical symptom and improve quality of life，andenhance better efficacy than western medicine.