Objective：To observe the clinical curative effect of Liqi Tongbian mixture combined with electroacupuncture for constipation-predominant irritable bowel syndrome(IBS-C)with spleen-deficiency and qi-stagnation syndrome.MethodsDivided 66 cases of IBS-C patients with spleen-deficiency and qi-stagnation syndrome into the experimental group and the control group， 33 cases in each group.Both groups were given actulose oral solution， while the experimental group additionally receivedLiqi Tongbian mixture combined with electroacupuncture for treatment.Treatment of both groups continuously lasted for four weeks.After treatment， evaluated clinical curative effect and changes of symptom score，detected brain-gut peptide level in plasma as well as anorectal dynamics parameters.ResultsThe total effective rate was 90.91%in the experimental group，being higher than 66.67%in the control group(P ＜0.05).After treatment，the scores of abdominal pain，abdominal distension，defecation frequency，defecate character，and a sense of incomplete evacuation in two groups all reduced when compared with those before treatment(P＜0.05)；the 5 symptom scores in the experimental group were all lower than those in the control group(P ＜ 0.05).After treatment，levels of plasma 5-hydroxytryptamine(5-HT)，serum substance P(SP)，and neuropeptide Y(NPY)in two groups were all lower than those before treatment(P ＜ 0.05).Levels of plasma 5-HT，serum SP，and NPY in the experimental group were all lower than those in the control group(P＜ 0.05).After treatment，the anal maximal squeezing pressure(MSP)of two groups and anal canal rest pressure(ARP)of the experimental group were all higher than those before treatment(P＜0.05).The maximum tolerable volume(MTV)of rectum intwo groups were lower than those before treatment(P＜0.05).MSP and ARP in the experimental group were both higher than those in the control group，while MTV being lower than that in the control group(P ＜ 0.05).ConclusionBased on therapy of lactulose oral solution，the additional application of Liqi Tongbian mixture combined with electroacupuncture for IBS-C with spleen-deficiency and qi-stagnation syndrome can reduce levels of plasma 5-HT，effectively regulate anorectal dynamics index and improve clinical syndromes，which shows significant effect.