Objective： To observe the clinical effect of Yiqi Zhenxin tang on reversion of ventricular remodeling for improving heart function.Methods：According to the method of numbering and random number generation，patients with chronic heart failure were divided into two groups，50 cases in each group.The control group was given systemic treatment of heart failure in terms of therapeutic principles of China Heart Failure Diagnosis and Treatment Guide(2014 Edition)，while the treatment group was additionally given Yiqi Zhenxin tang for treatment，the treatment being three months.Observed and evaluated the ventricular remodeling，indexes pertaining to heart function，scores of Chinese medicine clinical symptom，and changes of quality of life as well as adverse reaction.Results：The total effective rate of heart function effect was 80.0%in the treatment group and 72.0%in the control group；the total effective rate of Chinese medicine syndrome effect was 84.0%in the treatment group and 76.0%in the control group，differences being significant(P＜0.05，P＜0.01).Comparing with those before treatment， left ventricular ejection fraction(LVSD)， left ventricular end-systolic diameter(LVEF)detected by echocardiography in both groups were improved，while pro-brain natriuretic peptide(pro-BNP)was decreased；the 6-minute walk distance was prolonged；and scores of heart failure and quality of life of Nisuda were all decreased，differences being significant(P＜0.05，P＜0.01).Left ventricular end-diastolic diameter(LVDD)and left atrial diameter(LAD)were also improved，differences being significant(P ＜ 0.05).After treatment，comparing with those in the control group，the improvements of LVSD，LVDD，LAD，and LVEF in the treatment group were all better；the reduction of pro-BNP was more obvious；the 6-minute walk distance was longer；the reduction of scores of heart failure and quality of life of Nisuda were more obvious；Chinese medicine syndrome scores were lower，differences being significant(P ＜ 0.05).100 cases of patients were included in this study，and there were 6 cases of adverse reaction，which did not affect the data integrity.There were no significant differences being found in the comparison of blood，urine，stool for routine，liver function，kidney function，and electrolyte as well as other indexes between two groups(P＞0.05).Conclusion：Yiqi Zhenxin tang combined with systemic heart failure treatment can effectively improve heart function and has more advantages in reversing ventricular remodeling.